The adolescence period of life is crucial in an individual’s life as it is when a lot of changes occur physically and psychologically. The study was carried out among 240 adolescent students of classes 8 to 12 with the objective to assess, evaluate and compare substance use and substance use behaviour patterns among adolescent students. Descriptive statistics of N=240 reported, 81.7% had taken one or the other substances in the past; of which hookah smoking 66.3% was predominant, followed by alcohol 45%, marijuana 26.3% and Cigarettes 25% respectively. A one-way ANOVA revealed that there was a statistically significant difference in alcohol use between classes (F (4,235) = [10.41], p = <.001) and experimentation 59.2% (M=1.4, SD=.78) was the major contributor to substance use among adolescents followed by the following trend 42.5% (M=1.2, SD=.74), partying 42.1% (M=1.2, SD=.74), social media influence 20% (M=1, SD=.62), seeing family members 7.5% (M=.8, SD=.49), and peer group influence 6.3% (M=.88, SD=.48).